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화학과 세미나가 다음주 목요일(5월 25일) 오후 4시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : Functional Nanomaterials for Healthcare Applications연 사 : 이준석 교수님(한양대학교 화학과)일 시 : 2023년 5월 25일(목)오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================Functional Nanomaterials for Healthcare ApplicationsJoonseok Lee Recently, the area of nanostructure research is gradually moving toward the directions of the rational design of functional nanostructures for healthcare applications. In this talk, I will briefly overview recent progress and a collection of advances, particularly on the synthesis, characterization, and utilization of lanthanide-doped nanomaterials and 3D-networked porous nanostructures.Part 1) Near-infrared emitting nanoparticlesUpconversion nanoparticles (UCNPs) are promising materials for biological applications based on luminescence resonance energy transfer (LRET). In contrast to classical RET donors such as quantum dots, gold nanoparticles, UCNPs can emit near-infrared (NIR) upon the NIR irradiation, which provides enhanced signal-to-noise due to strong penetration and low autofluorescence in the NIR region known as the diagnostic window. Here we report the first efficient NIR-to-NIR signal-based LRET system for the detection of progesterone, chosen as a proof-of-concept target, via homogeneous competitive immunoassay. To enhance the efficiency of LRET, we constructed inert-core/active-shell/inert-ultrathin shell UCNPs as an LRET donor and a compact progesterone/horseradish peroxidase/IRdyeQC-1 (P-HRP-dyes) complex as an LRET acceptor. The designed donor and acceptor showed significantly improved LRET efficiencies (95% and 85% for donor and acceptor, respectively) compared with conventional donor and acceptor (70% and 50%, respectively). The efficient NIR-to-NIR signal-based LRET system has potential as a simple probe for homogeneous competitive immunoassay, with the ability to rapidly detect biomarkers.Part 2) 3D-networked highly porous nanostructuresAbnormal accumulation of β-amyloid (Aβ) peptide aggregates in brain is a major hallmark of Alzheimer's disease (AD). Aβ aggregates interfere with neuronal communications, ultimately causing neuronal damage and brain atrophy. Much effort has been made to develop AD treatments that suppress Aβ aggregate formation, thereby attenuating Aβ-induced neurotoxicity. Here, we report the design of Aβ nanodepletors consisting of ultra-large mesoporous nanostructures and anti-Aβ single-chain variable fragments (scFvs), with the goal of targeting and eliminating aggregative Aβ monomers. The Aβ nanodepletors impart a notable decline in Aβ aggregate formation, resulting in significant mitigation of Aβ-induced neurotoxicity in vitro. Furthermore, stereotaxical injections of Aβ nanodepletors into the brain of an AD mouse model system successfully suppress Aβ plaque formation in vivo up to ~30%, suggesting that Aβ nanodepletors can serve as a promising anti-amylodoisis material. * 졸업논문 교과목 수강자 세미나 필수 참석 안내석사, 석박통합, 박사과정이 수강하는 <졸업논문연구학점 1~6>수강자는 학과에서 개최하는 목요일 정규세미나에 반드시 참석해야함.관련공지(skku.edu)https://skb.skku.edu/chem/News/notice.do?mode=view&articleNo=146936&article.offset=10&articleLimit=10)
화학과 세미나가 다음주 월요일(5월 22일) 오후 4시 30분에 개최됩니다.장소는 화학관 1층 330126호실입니다.많은 참여 부탁드립니다.===============================================================================제 목 : Single photon interferometry and wave-particle duality연 사 : 조민행 교수님(고려대학교)일 시 : 2023년 5월 22일(월)오후 4시 30분장 소 : 화학관 1층 330126호실================================================================================ Single photon interferometry and wave-particle dualityMinhaeng Cho1,21Center for Molecular Spectroscopy and Dynamics, Institute for Basic Science (IBS), Seoul 02841, Republic of Korea2Dept. of Chemistry, Korea University, Seoul 02841, Republic of KoreaWave interferences are a common occurrence in nature and have been utilized in various interferometric processes in the time, frequency, and spatial domains. These processes have facilitated the development of remote-detection quantum spectroscopy with undetected photons, nonlinear optical or chiroptical spectroscopy, and interferometric Rayleigh and Raman scattering microscopy. Moreover, coherent multidimensional spectroscopy has proven to be useful in studying the molecular structure, anharmonic potential energy surface, and intermolecular interactions in condensed phases. In this lecture, I discuss the relationship between single-photon interferometry, quantitative wave-particle duality, spectroscopic dephasing, and quantum decoherence. By utilizing two entangled nonlinear bi-photon sources, we were able to prepare a quantum superposition of path-bin single-photon states with experimental control over the degree of quantum entanglement between quantons and detectors/environments. Measuring the interference of single photons allowed us to establish a quantitative complementarity relation between the wave and particle aspects of quantons. Furthermore, we demonstrated the experimental feasibility of remote-detection quantum spectroscopy with pairs of entangled photons by performing spectroscopy with undetected photons.
화학과 세미나가 다음주 목요일(5월 18일) 오후 4시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : Chimeric T Cells and Macrophages: Cell Engineering to Expand Their Therapeutic Potentials연 사 : 박희호 교수님(한양대학교 생명공학과)일 시 : 2023년 5월 18일(목)오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================ Chimeric T Cells and Macrophages:Cell Engineering to Expand Their Therapeutic Potentials Hee Ho Park 1,*1 Department of Bioengineering, Hanyang University,Seoul 04763, Republic of Koreaparkhh@hanyang.ac.kr Chimeric antigen receptor-T (CAR-T) cell immunotherapy has shown impressive clinical outcomes for hematologic malignancies. However, its broader applications are challenged due to its complex ex vivo cell-manufacturing procedures and low therapeutic efficacy against solid tumors. The limited therapeutic effects are partially due to limited CAR-T cell infiltration to solid tumors and inactivation of CAR-T cells by the immunosuppressive tumor microenvironment. Here, a facile approach is presented to in vivo program macrophages, which can intrinsically penetrate solid tumors, into CAR-M1 macrophages displaying enhanced cancer-directed phagocytosis and antitumor activity. In vivo injected nanocomplexes of macrophage-targeting nanocarriers and CAR-interferon-γ-encoding plasmid DNA induce CAR-M1 macrophages that are capable of CAR-mediated cancer phagocytosis, antitumor immunomodulation, and inhibition of solid tumor growth. Together, this study describes an off-the-shelf CAR-macrophage therapy that is effective for solid tumors and avoids the complex and costly processes of ex vivo CAR-cell manufacturing. Severe infectious diseases, such as coronavirus disease 2019 (COVID-19), can induce hypercytokinemia and multiple organ failure. In spite of the growing demand for peptide therapeutics against infectious diseases, current small molecule-based strategies still require frequent administration due to limited half-life and enzymatic digestion in blood. To overcome this challenge, a strategy to continuously express multi-level therapeutic peptide drugs on the surface of immune cells, is established. Here, chimeric T cells stably expressing therapeutic peptides are presented for treatment of severe infectious diseases. Using lentiviral system, T cells are engineered to express multi-level therapeutic peptides with matrix metallopeptidases- (MMP-) and tumor necrosis factor alpha converting enzyme- (TACE-) responsive cleavage sites on the surface. The enzymatic cleavage releases �-carboxyglutamic acid of protein C (PC-Gla) domain and thrombin receptor agonist peptide (TRAP), which activate endothelial protein C receptor (EPCR) and protease-activated receptor-1 (PAR-1), respectively. These chimeric T cells prevent vascular damage in tissue -engineered blood vessel and suppress hypercytokinemia and lung tissue damages in vivo, demonstrating promise for use of engineered T cells against sepsis and other infectious-related diseases.* 졸업논문 교과목 수강자 세미나 필수 참석 안내석사, 석박통합, 박사과정이 수강하는 <졸업논문연구학점 1~6>수강자는 학과에서 개최하는 목요일 정규세미나에 반드시 참석해야함.관련공지(skku.edu)https://skb.skku.edu/chem/News/notice.do?mode=view&articleNo=146936&article.offset=10&articleLimit=10)
화학과 세미나가 다음주 목요일(5월 11일) 오후 4시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : Single-Electron Oxidation-Induced Chemical Transformations: Carbon–Carbon Bond Formation and Selective Oxaziridine Rearrangement연 사 : 우상국 교수님(울산대학교)일 시 : 2023년 5월 11일(목)오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================Single-Electron Oxidation-Induced Chemical Transformations: Carbon–Carbon Bond Formation and Selective Oxaziridine Rearrangement Sang Kook WooDepartment of Chemistry, University of Ulsan, 93 Daehak-Ro, Nam-Gu, Ulsan 44610, KoreaEmail: woosk@ulsan.ac.kr Visible-light photoredox catalysis is an important research area in the field of green and sustainable organic synthesis. One of the main mechanisms involved in photoredox catalysis is single-electron transfer (SET), which has been extensively investigated in our group for the development of greener carbon–carbon bond forming reactions1 and oxaziridine rearrangement.2 In this presentation, I will describe our results on the development and application of neutral silicon radical precursors for the generation of alkyl radicals via SET and the selective rearrangement of oxaziridines into nitrones or amides. Herein, the recent our works will be discussed in detail.References(1) (a) Gontala, A.; Huh, H.; Woo, S. K. Org. Lett. 2023, 25, 21; (b) Nam, S. B.; Khatun, N.; Kang, Y. W.; Park, B. Y.; Woo, S. K. Chem. Commun. 2020, 56, 2873; (c) Khatun, N.; Kim, M. J.; Woo, S. K. Org. Lett. 2018, 20, 6239(2) (a) Park, J.; Park, S.; Jang, G. S.; Kim, R. H.; Jung, J.; Woo, S. K. Chem. Commun. 2021, 57, 9995; (b) Jang, G. S.; Lee, J.; Seo, J.; Woo, S. K. Org. Lett. 2017, 19, 6448 * 졸업논문 교과목 수강자 세미나 필수 참석 안내석사, 석박통합, 박사과정이 수강하는 <졸업논문연구학점 1~6>수강자는 학과에서 개최하는 목요일 정규세미나에 반드시 참석해야함.관련공지(skku.edu)https://skb.skku.edu/chem/News/notice.do?mode=view&articleNo=146936&article.offset=10&articleLimit=10)
화학과 세미나가 다음주 목요일(5월 4일) 오후 4시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : Electrocatalytic CO2 conversion technology for valuable chemical production연 사 : 이원희 박사님(한국에너지기술연구원)일 시 : 2023년 5월 4일(목)오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================Electrocatalytic CO2 conversion technologyfor valuable chemical productionWonhee LeeCarbon Conversion Research Laboratory, Climate Change Research Division,Korea Institute of Energy Research (KIER),152 Gajeong-ro, Yuseong-gu, Daejeon, 34129, Republic of KoreaInternational society has been making efforts to reduce greenhouse gas emission to alleviate the climate change. Since the carbon neutrality declaration by many countries in 2020, the world has established policies and strategies, and has enacted laws to achieve the carbon neutrality. The various key technologies capable of contributing to the greenhouse gas reduction target include photovoltaics, wind power, hydrogen, bioenergy, energy efficiency improvement, industrial decarbonization, and carbon capture, utilization and storage (CCUS). In particular, the CCUS technologies are considered to be the final ones to capture, convert and store the inevitably emitted CO2 from the industry. The electrochemical CO2 conversion is great attention as the promising technology to reduce CO2 electrochemically to value-added chemicals or fuels. To improve the CO2 conversion efficiency of the production of the valuable products, various obstacles including insufficient activity/selectivity of the CO2 reduction catalysts, low ionic conductivity of the ion-exchange membranes, and physicochemical/electrochemical stability of each component and the entire system. Additionally, the mechanisms of the electrochemical CO2 reduction and purverization of the catalysts are not clearly understood. Here, the recent research of electrochemical CO2 conversion will be introduced for the production CO2-derived carbon-neutral products. Additionally, formate production mechanism from CO2 on the SnOx surface with oxygen vacancy will be proposed as well.* 졸업논문 교과목 수강자 세미나 필수 참석 안내석사, 석박통합, 박사과정이 수강하는 <졸업논문연구학점 1~6>수강자는 학과에서 개최하는 목요일 정규세미나에 반드시 참석해야함.관련공지(skku.edu)https://skb.skku.edu/chem/News/notice.do?mode=view&articleNo=146936&article.offset=10&articleLimit=10)
화학과 세미나가 이번주 목요일(4월 20일) 오후 4시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : 화학과 선배가 들려주는 진로 이야기:전기 자동차 시장의 태동과 배터리 산업의 성장연 사 : 정원희 상무님(LG에너지솔루션)일 시 : 2023년 4월 20일(목)오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================화학과 선배가 들려주는 진로 이야기:전기 자동차 시장의 태동과 배터리 산업의 성장 발표자는 화학도로서 고분자 모델링과 물성 연구, 고분자 합성 촉매 개발로 유기금속화학 박사 학위를 취득하였습니다. 학위 과정 중 여러 고수분에게 많은 도움과 영향을 받으며 미래 진로를 고민하였고, 자동차용 전지 개발 분야에 뛰어들었습니다. 현재에는 LG Energy Solution에서 자동차용 리튬 이온 전지 제품 개발을 담당하고 있습니다.이번 세미나에서는 화학 전공자가 자동차전지 개발자가 되기까지의 과정에서 만난 은사님, 노벨상 수상자, 선배님 등, 여러 고수분들의 이야기와 그 분들로부터 배운 점들을 나누고자 합니다. 또한 최근 급성장하고 있는 전기 자동차 시장과 이차 전지 산업 내용도 소개하여, 화학과 후배들의 진로 고민에 조금이나마 도움이 되고자 합니다.* 졸업논문 교과목 수강자 세미나 필수 참석 안내석사, 석박통합, 박사과정이 수강하는 <졸업논문연구학점 1~6>수강자는 학과에서 개최하는 목요일 정규세미나에 반드시 참석해야함.관련공지(skku.edu)https://skb.skku.edu/chem/News/notice.do?mode=view&articleNo=146936&article.offset=10&articleLimit=10)
화학과 세미나가 이번주 목요일(4월 13일) 오후 4시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : Pressure enabled organic reactions via confinement between graphene layers연 사 : 신현석 교수님(UNIST)일 시 : 2023년 4월 13일(목)오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================Pressure enabled organic reactions via confinement between graphene layers Hyeon Suk Shin Department of Chemistry & Low-Dimensional Carbon Materials Center, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea Chemical reactions conducted at high pressures provide opportunities for realising new synthesis chemistries and achieving novel states of matter. Many industrial chemical reactors operate at pressures of few thousand atmospheres but facile application of very high pressures (>1 GPa), where interesting reactions can occur and new materials can be realized, is challenging. Confinement of reactants within nanoscale spaces of low dimensional materials (pores such as zeolites and metal organic frameworks and carbon nanotubes) has been shown to provide non-equilibrium conditions for synthesis of novel molecules3 and tuning of chemical reactivity. While few studies have reported chemistry within zero dimensional pores and one dimensional nanotubes, organic reactions in confined spaces between 2D materials have yet to be explored. Here we demonstrate that reactants confined between atomically thin sheets of graphene or hexagonal boron nitride experience pressures as high as 7 GPa, which allows the propagation of solvent-free organic reactions that ordinarily do not occur under standard conditions. Specifically, we show that cyclodehydrogenation of hexaphenylbenzene without catalysts as a proof of concept and oxidative polymerisation of dopamine into sheet-like crystalline structure are enabled by the effective high pressure experienced by the reactants between the graphene layers. The graphene/polydopamine/graphene reaction results in a novel composite material that possesses higher Young’s modulus (430 GPa) than pure graphene layers (300 GPa) and an exceptionally low water vapor transmission rate of < 0.1 g-m-2-day-1 – nearly an order of magnitude lower than the state-of-the-art water-diffusion barriers for graphene and hBN. Our results demonstrate a facile, general approach for performing new high-pressure chemistry based on confinement of reactants within graphene layers that provides opportunities for realizing new materials with extraordinary properties.* 졸업논문 교과목 수강자 세미나 필수 참석 안내석사, 석박통합, 박사과정이 수강하는 <졸업논문연구학점 1~6>수강자는 학과에서 개최하는 목요일 정규세미나에 반드시 참석해야함.관련공지(skku.edu)https://skb.skku.edu/chem/News/notice.do?mode=view&articleNo=146936&article.offset=10&articleLimit=10)
다원앤컴퍼니 조서윤 대표님(화학과 78학번)의 플래너리 세미나 안내드립니다.학부생, 대학원생 여러분의 많은 참석 부탁드립니다.감사합니다.======================================연 사 : 조서윤 대표님(다원앤컴퍼니)일 시 : 2023년 4월 6일(목) 오후 4시 30분장 소 : 화학관 1층 첨단강의실(330118호실)--------------------------------------*다원앤컴퍼니(DAWON & Company) : http://www.dawon.com* 졸업논문 교과목 수강자 세미나 필수 참석 안내석사, 석박통합, 박사과정이 수강하는 <졸업논문연구학점 1~6>수강자는 학과에서 개최하는 목요일 정규세미나에 반드시 참석해야함.관련공지(skku.edu)https://skb.skku.edu/chem/News/notice.do?mode=view&articleNo=146936&article.offset=10&articleLimit=10)
화학과 세미나가 이번주 목요일(3월 30일) 오후 4시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : Bio-inspired Material Assembly and Applications연 사 : 이승욱 교수님(UC버클리)일 시 : 2023년 3월 30일(목)오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================Bio-inspired Material Assembly and Applications Professor Seung-Wuk Lee Bioengineering, University of California, BerkeleyLawrence Berkeley National Laboratory, Berkeley, CA 94720 USA AbstractIn nature, helical macromolecules such as collagen, chitin and cellulose are critical to the morphogenesis and functionality of various hierarchically structured materials. During morphogenesis, these chiral macromolecules are secreted and undergo self-templating assembly, a process whereby multiple kinetic factors influence the assembly of the incoming building blocks to produce non-equilibrium structures. A single macromolecule can form diverse functional structures when self-templated under different conditions. Collagen type I, for instance, forms transparent corneal tissues from orthogonally aligned nematic fibers, distinctively colored skin tissues from cholesteric phase fiber bundles, and mineralized tissues from hierarchically organized fibers. Nature’s self-templated materials surpass the functional and structural complexity achievable by current top-down and bottom-up fabrication methods. However, self-templating has not been thoroughly explored for engineering synthetic materials. In my seminar, I will demonstrate a facile biomimetic process to create functional nanomaterials utilizing chiral colloidal particles (M13 phage). A single-step process produces long-range-ordered, supramolecular films showing multiple levels of hierarchical organization and helical twist. Using the self-templating materials assembly processes, we have created various biomimetic supramolecular structures. The resulting materials show distinctive optical and photonic properties similar to avian skin color matrices and butterfly wing nanostructures. Through the directed evolution of the M13 phages, I will also show how resulting materials can be utilized as functional nanomaterials for biomedical, biosensor and bioenergy applications.* 졸업논문 교과목 수강자 세미나 필수 참석 안내석사, 석박통합, 박사과정이 수강하는 <졸업논문연구학점 1~6>수강자는 학과에서 개최하는 목요일 정규세미나에 반드시 참석해야함.관련공지(skku.edu)https://skb.skku.edu/chem/News/notice.do?mode=view&articleNo=146936&article.offset=10&articleLimit=10)
해외저명대학 교원초청 특별 세미나가 3월 30일(목) 및 4월 11일(화)에 개최됩니다.많은 참여 부탁드립니다.==========================================================================1. 강연자: Professor Seung-Wuk Lee- Department of Bioengineering, University of California, Berkeley (2006~present)- Virus를 이용한 나노바이오 소재에 대한 세계적 권위자- American Institute for Medical and Biological Engineering's College of Fellows (2016)- One of 12 Highlights for President Obama’s US Congress report for the NSF (2014) 2. 특강 주제 및 내용:(주제) Bionanoscience and Bionanomaterials:- What is the characteristic of bionanomaterials.- How to develop bionanomaterial to solve real world problems.3. 주관: 자연과학대학 화학과 (고두현교수 재료화학1수업) 4. 일시 및 장소:-1차 오프라인강연: 2023년3월30일 오전10:20~11:50 / 화학관 330126-2차 온라인강연: 2023년4월11일 오전9:00~10:305. Zoom 참석 링크-1차:https://us02web.zoom.us/j/83698318067?pwd=VHgyQkI3NWdMdnJTTk1ydHF0VXgxQT09-2차: https://us02web.zoom.us/j/88538703319?pwd=a0lRd09veVZzYXhyU2ZDdWhrZ2JCZz09 6. 문의: (화학과 행정실) 031-290-7099* 참여학생들은 Video On, Mic Off 하여 주시기 바랍니다.
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