The research team led by Prof. Geun-hyung Kim Succeeded in regenerating muscle tissue by developing bio-technologies
The research team of the Dept. of Bio-Mechatronic Engineering Succeeded in regenerating muscle tissue by developing bio-ink and cell-printing technologies
-Increases muscle tissue regeneration dramatically through the development of artificial tissues that lead to the growth and arrangement of muscle cells and tissues.
The team led by Prof. Geun-hyung Kim, the Dept. of Bio-Mechatronic Engineering, has succeeded in developing bio-making technology that can regenerate muscle tissue and bio-ink for cell-printing that includes living cells. The research team enhanced the tissue regeneration effect by inducing living cells in bio-ink to grow in one direction, just like the actual muscles.
Organizational regenerative engineering has been developed with the goal of maximizing regenerative effect by transplanting artificial tissue similar to actual tissue in the area of the human lesion. For this purpose, cell-printing, which produces artificial tissue from bio-ink containing living cells, is being used. Today's commonly used bio-ink and cell-printing processes have limited to cell alignment.
The team led by Prof. Geun-hyung Kim developed the existing bio-material-based bio-ink based on two technologies that control the growth and arrangement of cells through the cell-printing process.
"The research is a new concept of cell-printing process technology that controls the arrayability of nanoparticles or directly arranges cells through synthetic polymer. ", said Prof. Kim. "This technique is a more effective and new way to regenerate not only skeletal muscle but also the arrayed tissue existing in the human body, such as myocardium and ligaments," he explained.
The studies were conducted with the support of the basic research support project of National Research Foundation of Korea (the Ministry of Education and Science Technology). These studies were also published in the world-renowned journal Nano Letters (impact factor 12.279) and Biomaterials (impact factor 10.273), the top international journals in the field of biomaterials.
Figure 1. Cell growth, maturation, and successful regeneration of muscle tissue produced with 3D cell-printing mimetic diagram using collagen-based bio-ink including gold-nano particles.
Figure 2. 3D cell-printing mimetic diagram of arranged phototropic exoplastic cell structures and comparison of cell activity and maturity with arrayed gelatin-based structures and cell structures of general extracellular matrix
(source: ChosunBiz, https://biz.chosun.com/site/data/html_dir/2019/11/27/2019112702158.html?utm_source=naver&utm_medium=original&utm_campaign=biz
- No new post