-
- Graduate student Han Jihoon and Lee Jeongmi win SKKU Graduate Student thesis award
- At the 2021 SKKU Graduate Student Thesis Award, which was implemented as part of the 4th stage BK21 graduate school innovation support project, School of pharmacy doctoral student Han Jihoon received the best thesis award, and doctoral student Lee Jeongmi received the excellent thesis award. There were a total of 273 applicants for the project, and the field of science and engineering reached a acceptance rate of 8:1. Congratulations on Han Jihoon and Lee Jeongmi for winning the awards through their excellent research skills. *Best Thesis Award : Han Jihoon(Ph. D course, Advisor Jo Dong-Gyu) _ Exosome-mediated efficient intracellular delivery of cargo proteins using a novel light-induced cargo protein release system *Excellent Thesis Award : Lee Jeongmi(Ph. D course, Advisor Jo Dong-Gyu) _ Extracellular vesicles from adipose-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p
-
- 작성일 2021-11-01
- 조회수 2666
-
- Professor In Su Kim wins the 24th Jang Se Hee Academic Award
- Professor In Su Kim won the 24th Jang Se Hee Academic Award at 128th General Meeting of the Korean Chemical Society held at BEXCO in Busan on October 14 (Thu), 2021. The Jang Se Hee Academic Award was established in 1998 to honor the Professor Se Hee Jang, a recognized authority on organic chemistry, and is awarded annually to researchers who have published international research results related to organic chemistry. Professor In Su Kim was selected as the winner for his world-class research achievements in the fields of introduction of new functional device through carbon-hydrogen bonds using transition metal catalysts, synthesis and conversion of heterocyclic compounds, which are the core unit structure of pharmaceuticals, and synthesis of natural products. Since joining at Sungkyunkwan University in 2012, Professor Kim has published 130 SCI(E) papers and 25 patents registered, and is currently serving as the director of basic research institute project at National Research Foundation of Korea, and working on mid-career research support project and bio-medical development project.
-
- 작성일 2021-10-20
- 조회수 2924
-
- Research team led by Professor Jo Dong-gyu publishes a paper in Journal of Extracellular Vesicles
- Professor Jo Dong-gyu's research team has published a new research result that can be applied to the prevention and treatment of osteoporosis. The research team confirmed the therapeutic effect in osteoporosis through exosomes derived from adipose stem cells and investigated the mechanism of action that inhibits the differentiation into osteoclasts. In bone tissue of osteoporotic patients, differentiation of osteoclasts by RANKL is over-activated, and the expression level of Osteoprotegerin, a natural inhibitor of RANKL, is low. In addition, miRNA (microRNA) is an important factor regulating bone function and metabolism, and it has been reported that the expression pattern of miRNA in the serum of osteoporosis patients is different from that of normal people. The team confirmed that the decreased bone density was restored when adipose stem cell-derived exosomes were administered to an animal model of osteoporosis induced by resection of the ovaries for two weeks. In addition, it was confirmed that the adipose stem cell-derived exosome inhibits the differentiation of osteoclasts and promotes the migration of bone marrow mesenchymal stem cells. Component analysis was conducted to identify the mechanism of action of adipose stem cell-derived exosomes, and it was confirmed that Osteoprotegerin and various miRNAs, which are low in expression in osteoporosis, were present in the exosomes. In the case of exosomes deficient in osteoprotegerin, it was revealed that the therapeutic effect of adipose stem cell-derived exosomes was dependent on Osteoprotegerin through the absence of an osteoclast inhibitory effect and no therapeutic effect on osteoporosis. In addition, it was suggested as a new therapeutic target for osteoporosis by confirming that osteoclast differentiation was inhibited when miR-21-5p and let-7b-5p were overexpressed. In addition, it was found that when adipose stem cell-derived exosomes were administered intravenously, they were effectively delivered to bone tissue. Based on these results, the team presented a potential as a new therapeutic agent for osteoporosis by delivering therapeutic factors to bone tissue using adipose stem cell-derived exosomes in osteoporosis and inhibiting the differentiation of osteoclasts. Professor Jo Dong-gyu said, “It is speculated that cytokines and miRNAs contained in adipose stem cell-derived exosomes are related to osteoclast and osteoclast differentiation. This study may suggest a new direction for overcoming osteoporosis.” The research results were published in the October issue of ‘Journal of Extracellular Vesicles’ (IF 25.841), a world-renowned journal. This research was conducted through joint research with Professor Jo Dong-gyu's research team and the research team of Cho Yong-woo of Hanyang University. The research was supported by the Ministry of Science and ICT (Minister Hye-sook Lim), Mid-career researcher grant fundedby the National Research Foundation (Chairman Gwang-bok Lee), the Leading Research Center(MRC), and the Ministry of Food and Drug Safety. Title: Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p Authors: Jeongmi Lee (Ph.D. program, first author), Hakkyun Kim (Ph.D., co-author), Ji-Hoon Han (Ph.D., co-author), Eunae Kim (Ph.D., co-author), Jae-Hoon Seol (Ph.D., co-author), Dong-Gyu Jo (Professor) , corresponding author)
-
- 작성일 2021-10-18
- 조회수 2669
-
- Research professor Yi Sang Ah publishes a paper in Advanced Materials
- Research Professor Lee Sang-ah(1st author) and Professor Lee Ki-beom Lee's research team at Rutgers New Jersey State University wrote a review paper on the latest bioengineering technology in organoid research. Organoids, organ analogues that are differentiated from stem cells in three dimensions, are used for drug development, disease treatment, and artificial organ development. However, due to various technical limitations, it is difficult to make it identical to an actual organ, and many studies are being attempted worldwide to overcome this issue. This paper deals with various cutting-edge technologies for making organoids similar to organs in the human body and applying them to clinical treatment. The research has been supported the Presidential Post Doc. Fellowship funded by National Research Foundation of Korea and was published in a world-renowned academic journal, Advanced Materials (IF 30.849) with an early view on September 24.
-
- 작성일 2021-10-18
- 조회수 2782
-
- Professor Jo Dong-gyu's research team publishes a paper in Theranostics
- A research team led by Professor Jo Dong-gyu (first author: Han Jihoon, combined Master/Ph.D course) revealed the mechanism on how Presenilin-1 mutations, which are known to be the main cause of hereditary Alzheimer's dementia, affect mitochondria. This study was conducted based on the fact that mitochondrial dysfunction and oxidative stress are detected in the early stages of Alzheimer's disease and that Presenilin-1 is present in various intracellular organelles including mitochondria. The team found that the mutation of Presenilin-1 abnormally increases the binding of ER and mitochondria by increasing the expression of ATL2, and that the expression level of ATL2 is increased in Alzheimer's patients and Alzheimer's mouse model brains. This study was carried out with the support of the Ministry of Science and ICT's Mid-career research grant and the Leading Research Center (MRC), and was published in the September issue of Theranostics (IF 11.56), a world-renowned academic journal. * Title: Alzheimer’s disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function
-
- 작성일 2021-10-18
- 조회수 2258
-
- Professor Chung Ka Young's research team publishes a paper in PNAS
- Professor Chung Ka Young's research team (first author Dr. course Park Ji Young, M.S. course Yun Min Woo) announced that they have identified the mechanism how Arrestin scaffolds ERK signaling proteins through joint research with Professor Jinpeng Sun of Shandong University. Arrestin is known to promote ERK signaling as a major sub-signaling protein of the G protein-coupled receptor. However, the exact mechanism was unknown. Therefore, the research team studied the structural principle that Arrestin and ERK signaling proteins combine to reveal the principle that Arrestin promotes ERK signaling. The research was carried out with the support of the Ministry of Science, ICT and Future Planning Mid-career Research Grant and the Leading Research Center (MRC), and was published in the September issue of Proceedings of the National Academy of Sciences of the USA (IF 11.205). Title: Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade
-
- 작성일 2021-10-18
- 조회수 2259
-
- Former School of Pharmacy Student Presidents publish papers in world-renowned journals
- Professor Kim In Su's research team published papers on the July issue of 'Organic Letters (IF = 6.091, JCR ranking = 7.0%)', a world-renowned scientific journal in the field of chemistry (1st author: Park Min Seo, master's course, co-first author: Moon Kyeongwon, 6th grade undergraduate) and on the Auguest issue of 'The Journal of Organic Chemistry (IF = 4.335, JCR ranking = 15.7%)' (1st author: Byun Youjung, master's course). The findings of Professor Kim In Su's research team are development of synthesis and transformation reaction on a major heterocyclic skeleton in pharmaceuticals through the introduction of novel functional groups. The N-heterocyclic skeleton is known as the core skeleton of pharmaceuticals and natural products. The team published the results of synthesizing indazole and dihydrocinnolinone structures, known as key pharmacological groups, through intramolecular cyclization after linking azobenzene and vinylene carbonate structures using a very small amount of a rhodium catalyst in the journal, 'Organic Letters'. The indazole structure is the core skeletal structure of drugs with anti-inflammatory, vascular homeostasis, anticancer and antiemetic activities, and the dihydrocinnolinone structure is the core skeletal structure of drugs with antibiotic and antifungal activities. In addition, another Professor Kim In Su's research team developed a radical generation under eco-friendly conditions that do not use metal, and further developed these reaction conditions on introducing alkyl and acyl groups into carbon-hydrogen bonds in benzoxazinone and published in The Journal of Organic Chemistry. The Benzoxazinone structure is known to have anticancer and antibiotic activities, and has a skeletal structure similar to that of a pyruvate kinase activator. The findings have also proposed a new molecular structure synthesis method by expanding the scope of application of various heterocyclic heterocycles to compounds having a parent nucleus through heteroarylation of the benzoxazinone structure.
-
- 작성일 2021-10-18
- 조회수 2232
-
- JPR publishes Professor Lee Hyo-Jong's paper as a cover of its August issue
- A research team led by Professor Lee Hyo-Jong (First author, Ph.D course Hwang Su Jung ) announced that the team has developed an anti-cancer treatment substance that simultaneously inhibits the growth of cancer cells and the formation of blood vessels in the cancer microenvironment through a joint research with Professor Park Yo-Han of Inje University. Hypoxia-inducible factor-1α (HIF-1α) protein is a key factor which regulates cancer cell division, angiogenesis, invasion and metastasis in the cancer microenvironment. Therefore, research on the development of its inhibitors is being actively conducted. Melatonin is a natural hormone produced by the pineal gland in the body and exhibits anticancer activity by regulating HIF-1α, but has a problem of low bioavailability. Accordingly, the research team derived a melatonin analogue (NB-5-MT) that improved the absorption rate into cancer cells with remarkably low toxicity through minimal chemical structural modification from the natural hormone melatonin, and NB-5-MT It was confirmed through animal experiments that it inhibits not only the growth but also the formation of blood vessels in the cancer microenvironment. Furthermore, it was found that NB-5-MT exhibited superior effects in not only improved cell uptake, but also decreased HIF-1α protein expression, decreased transcription of HIF-1α target gene, decreased reactive oxygen species (ROS), and suppressed tumor size and metastasis. Professor Lee Hyo-Jong said, “It is very meaningful to discover an improved melatonin-better that compensates for the shortcomings of melatonin, a natural anticancer hormone, and maximizes its effects. It presented the possibility of developing a dual-action new drug that simultaneously inhibits cancer cells and their surrounding microenvironment, and is expected to be used in vascular diseases such as macular degeneration.” This research was carried out with the support of the Ministry of Science and ICT's Support for Outstanding New Researchers, the Gene-Donguibogam Project based on Traditional Natural Products, and the Project for Fostering the Next Generation in Science and Engineering. It is published as a cover paper in the August issue, JOURNAL OF PINEAL RESEARCH. (IF 13.007, JCR ranking 3.09%) * Title: Enhanced anti-angiogenic activity of novel melatonin-like agents
-
- 작성일 2021-10-18
- 조회수 2266
-
- SKKU selected in MFDS 'Regulatory Science Talent Development' to establish 'Biohealth Regulatory Science' department
- Sungkyunkwan University was finally selected in “University Project for Talent Development in Drug Efficacy Evaluation”, supported by the Ministry of Food and Drug Safety (Research Director, Professor Ju-young Shin, School of Pharmacy). Based on this project, SKKU established the “Department of Biohealth Regulatory Science” in the general graduate school and will receive a total of 2.5 billion won in project expenses for 5 years to foster key master’s and doctoral talents who will lead the advancement of the drug efficacy evaluation field. The project will be operated based on a cooperative system. A total of 28 faculty members participated in the project, including not only the School of Pharmacy, but also the School of Medicine, Samsung Convergence Medical Science Institute, Samsung Seoul Hospital, Kangbuk Samsung Hospital, Artificial Intelligence College, and pharmaceutical/bio venture companies. In addition, development and operation of a customized curriculum specialized in the field of drug efficacy evaluation, discovery and implementation of projects tailored to demand, student support and field training will be provided. The Bio-Health Regulatory Science major track is largely composed of “Data Science,” “Advanced Biotechnology,” and “Clinical Trial Innovation”. developed. In addition, in order to strengthen research capacity, we plan to discover and conduct practical-solving research topics needed by industry and government, and we plan to utilize the R&D centers established in the university, such as the Global New Drug Research Center and the Clinical Medicine Research Center, as a research platform. The main participating professors for each track are as follows. ▲Data Science Track: Ju-Young Shin (Pharmaceutical Epidemiology), Ji-Hyeong Lee (Artificial Intelligence), Yoo-Soo Jang (Clinical Epidemiology), Hoon Kim (Computational Biomedicine) ▲Advanced biotechnology track: Choon-Gon Chang (Neuropharmacology), Chung Sang-Jeon (Chemical Biology), Jae-Cheol Lee (Drug Immunology), Jae-Wook Ko (Director of Smart Healthcare Research Center, Samsung Seoul Hospital, Clinical Pharmacology), Hye-Ryeon Chang (Clinical Medicine, Nephrology) ▲ Clinical trial innovation track: Woo-Sung Ho (Director of Clinical Medicine Research Center, Samsung Medical Center, Department of Nephrology), Yeon-Hee Park (Director, Department of Hematology and Oncology, Samsung Medical Center), Joo-Hee Jo (Samsung Convergence Medical Science Institute, Clinical Epidemiology), Jae-Hyeon Lee (Regulatory Science) ), Byungchang Jeong (Director, Laboratory Animal Research Center, Samsung Seoul Hospital, Department of Urology)
-
- 작성일 2021-10-18
- 조회수 2247
-
- Five graduate students selected for 2021 Ph.D research incentive project
- Five graduate students were finally selected for the 2021 Ph.D. student research incentive project. Kwon Na-yeon (advisor: Kim In Su), Noh Yun-ha (advisor: Shin Ju-young ), Seon-young Park (advisor: Jo Dong-gyu), Lee Jin-sol (advisor: Kim Hyungsik), Ham Dong-hee (advisor: Chung Ka Young) The National Research Foundation of Korea's 'Ph.D. Student Research Incentive Project' supports the research of doctoral students (including combined master's and doctoral students and graduates) in the basic science and technology field to nurture young researchers. With this selection, five Ph.D. students will receive a research grant of 40 million won for two years. Hearty congratulations on your selection.
-
- 작성일 2021-10-18
- 조회수 2288