Former School of Pharmacy Student Presidents publish papers in world-renowned journals
- 약학대학
- Hit3039
- 2021-10-18
Professor Kim In Su's research team published papers on the July issue of 'Organic Letters (IF = 6.091, JCR ranking = 7.0%)', a world-renowned scientific journal in the field of chemistry (1st author: Park Min Seo, master's course, co-first author: Moon Kyeongwon, 6th grade undergraduate) and on the Auguest issue of 'The Journal of Organic Chemistry (IF = 4.335, JCR ranking = 15.7%)' (1st author: Byun Youjung, master's course).
The findings of Professor Kim In Su's research team are development of synthesis and transformation reaction on a major heterocyclic skeleton in pharmaceuticals through the introduction of novel functional groups. The N-heterocyclic skeleton is known as the core skeleton of pharmaceuticals and natural products. The team published the results of synthesizing indazole and dihydrocinnolinone structures, known as key pharmacological groups, through intramolecular cyclization after linking azobenzene and vinylene carbonate structures using a very small amount of a rhodium catalyst in the journal, 'Organic Letters'. The indazole structure is the core skeletal structure of drugs with anti-inflammatory, vascular homeostasis, anticancer and antiemetic activities, and the dihydrocinnolinone structure is the core skeletal structure of drugs with antibiotic and antifungal activities.
In addition, another Professor Kim In Su's research team developed a radical generation under eco-friendly conditions that do not use metal, and further developed these reaction conditions on introducing alkyl and acyl groups into carbon-hydrogen bonds in benzoxazinone and published in The Journal of Organic Chemistry. The Benzoxazinone structure is known to have anticancer and antibiotic activities, and has a skeletal structure similar to that of a pyruvate kinase activator. The findings have also proposed a new molecular structure synthesis method by expanding the scope of application of various heterocyclic heterocycles to compounds having a parent nucleus through heteroarylation of the benzoxazinone structure.