① 연구실명 : 분자 피부 과학 연구실(Molecular Dermatology Lab)
② 지도교수명 : 이종성 교수님(Prof. Lee, jongsung)
③ 연구실 소개
안녕하세요 성균관대학교 생명공학대학 융합생명공학과 이종성 교수님 '분자 피부 과학 연구실' 입니다. 저희 연구실에서는 외부 자극에 의해 발생하는 다양한 피부 이상 현상 (피부암, 피부 자가면역질환, 노화, 피부염증 질환, 색소이상 등)의 발생 기전에 대해 연구하고 있으며 더 나아가 피부이상을 개선할 수 있는 소재개발에 관한 연구도 진행하고 있습니다. 또한, 피부 및 피하조직 세포들의 매커니즘 연구를 통하여 전반적인 피부의 항상성 유지 및 피부를 개선할 수 있는 연구에 초점을 맞추고 있습니다. 졸업 후에는 생명공학 및 코스매틱 기반의 연구실이나 연구 시설 등으로 진출합니다.
This is the 'Molecular Dermatology Laboratory' of Professor Jong-Sung Lee, Department of integrative Biotechnology, College of Biotechnology, Sungkyunkwan University. In our laboratory, we research the mechanisms of occurrence of various skin abnormalities such as skin cancer, skin autoimmune diseases, aging, skin inflammatory diseases, pigment abnormalities, etc. caused by external stressors and further develop materials that can improve skin conditions. In addition, we focus on research that can improve the skin condition and maintain overall skin homeostasis through research on the mechanisms of skin and subcutaneous tissue cells. After graduation, our alumni can work in biotech and cosmetics-based laboratories or research facilities.
④ 연구분야
피부 생리 및 항상성 연구/ 피부 색소(멜라닌) 형성 / 피부 염증 및 자가면역질환 / 노화
skin physiology & homeostasis mechanism / melanogenesis / skin inflammatory and autoimmune disease / aging
⑤ 대표연구 실적
■ The Role of Leptin in the Association between Obesity and Psoriasis. Hwang J, Yoo JA, Yoon H, Han T, Yoon J, An S, Cho JY, Lee J. Biomol Ther (Seoul). 2020 Jul 21. doi: 10.4062/biomolther.2020.054. Online ahead of print.
■ Glucose Exerts an Anti-Melanogenic Effect by Indirect Inactivation of Tyrosinase in Melanocytes and a Human Skin Equivalent. Lee SH, Bae IH, Lee ES, Kim HJ, Lee J, Lee CS. Int J Mol Sci. 2020 Mar 3;21(5):1736. doi: 10.3390/ijms21051736.
■ Melanogenic Effects of Maclurin Are Mediated through the Activation of cAMP/PKA/CREB and p38 MAPK/CREB Signaling Pathways. Hwang YS, Oh SW, Park SH, Lee J, Yoo JA, Kwon K, Park SJ, Kim J, Yu E, Cho JY, Lee J. Oxid Med Cell Longev. 2019 Dec 22;2019:9827519. doi: 10.1155/2019/9827519. eCollection 2019.
■ Antagonizing Effects of Clematis apiifolia DC. Extract against Benzo[a]pyrene-Induced Damage to Human Keratinocytes. Lee SE, Park SH, Yoo JA, Kwon K, Kim JW, Oh SW, Park SJ, Kim J, Yu E, Han BS, Cho JY, Lee J. Oxid Med Cell Longev. 2019 Nov 5;2019:2386163. doi: 10.1155/2019/2386163. eCollection 2019.
■ Interleukin4Rα (IL4Rα) and IL13Rα1 Are Associated with the Progress of Renal Cell Carcinoma through Janus Kinase 2 (JAK2)/Forkhead Box O3 (FOXO3) Pathways. Kang MA, Lee J, Ha SH, Lee CM, Kim KM, Jang KY, Park SH. Cancers (Basel). 2019 Sep 18;11(9):1394. doi: 10.3390/cancers11091394.
■ Beauvericin inhibits melanogenesis by regulating cAMP/PKA/CREB and LXR-α/p38 MAPK-mediated pathways. Lee SE, Park SH, Oh SW, Yoo JA, Kwon K, Park SJ, Kim J, Lee HS, Cho JY, Lee J. Sci Rep. 2018 Oct 8;8(1):14958. doi: 10.1038/s41598-018-33352-8.
■ Globular adiponectin acts as a melanogenic signal in human epidermal melanocytes. Kim Y, Cho JY, Oh SW, Kang M, Lee SE, Jung E, Park YS, Lee J. Br J Dermatol. 2018 Sep;179(3):689-701. doi: 10.1111/bjd.16488. Epub 2018 Jul 4.
■ Stemness and differentiation potential-recovery effects of sinapic acid against ultraviolet-A-induced damage through the regulation of p38 MAPK and NF-κB. Hwang YS, Park SH, Kang M, Oh SW, Jung K, Park YS, Lee J. Sci Rep. 2017 Apr 19;7(1):909. doi: 10.1038/s41598-017-01089-5.
⑥ 대표전화 : 031-290-7891
⑦ 위치 : 62251B