① 연구실명 : 발생생식분자생물학연구실(Molecular Biology of Development and Reproduction)
② 지도교수명 : 오정수 교수님(Prof. Oh, Jeong Su)
③ 연구실 소개
안녕하세요, 저희는 성균관대학교 생명공학대학 융합생명공학과 오정수 교수님 '발생생식분자생물학 연구실' 입니다. 발생생식분자생물학 연구실은 생식세포 및 초기 배아 발생과정에서 일어나는 일련의 생명현상을 분자적인 수준에서 연구하는 실험실입니다. 특히나 난자는 발생과 동시에 감수분열 초기단계에서 세포주기가 멈춰있게 됩니다. 따라서, 세포주기 조절기작을 연구하기 위한 중요한 모델시스템으로써 활용될 수 있습니다. 본 연구실은 난자를 통해서 새로운 세포주기 조절인자를 탐색하고 이를 암세포와 같은 체세포에 응용함으로써 새로운 항암치료제를 개발하고자 합니다. 또한, 초기 배아 발생과정에서 일어 나는 유전자의 리프로그래밍 기작을 연구함으로써 줄기세포의 유전자 조절기작을 이해하고자 합니다. 저희 연구실의 대표 전화는 031-290-7865이며 이메일 주소는 ohjs@skku.edu이오니 관심있는 분들께서는 언제든 연락주시기 바랍니다. 감사합니다.
Our research focuses on the molecular mechanisms that regulate gamete maturation, fertilization, and preimplantation development. We are also interested in the epigenetic reprogramming during the egg-to-embryo transition. Mammalian oocytes are arrested at the prophase of the first mieosis. Therfore, oocytes is used as an important model system to study cell cycle regulation. Moreover, Our lab seeks to decvelop new anticancer drugs by searching for new cell cycle regulators through oocytes. In addition, studying the reprogrramming mechanisms of genes that occur during early embryonic development process, we intend to understand the mechanisms of stem cell gene regulation.
④ 연구분야
감수 분열 세포주기 조절, 상동염색체분리및 이수성, 난자의 질 조절, 수정과정중의 염색질 리모델링
Regulation of meiotic cell cycle, Homologous chromosome segregation and aneuploidy, Control of oocyte quality, Chromatin remodeling during fertilization
⑤ 대표연구 실적
■ Guang-Yu Bai, Min Ho Choe, Jae-Sung Kim, Jeong Su Oh, Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/CCdh1 regulation during meiotic G2/M transition in mouse oocytes, Development 2020 147: dev185322 doi: 10.1242/dev.185322 Published 27 April 2020
■ Jeon, Hyuk-Joon, Bai, Guang-Yu, Park, Yuram, Kim, Jae-Sung, Oh, Jeong Su, Prevention of quality decline and delivery of siRNA using exogenous TCTP translocation across the zona pellucida in mouse oocytes. Scientific Reports. 12/11/2019, Vol. 9 Issue 1, p1-8. 8p. 10.1038/s41586-020-2140-0. Epub 2020 Mar 25.
■ Jiyeon Leem, Guang‐Yu Bai, Jae‐Sung Kim, Jeong Su Oh, Melatonin protects mouse oocytes from DNA damage by enhancing nonhomologous end‐joining repair, Journal of Pineal ResearchVolume 67, Issue 4, https://doi.org/10.1111/jpi.12603
■ Jaehwan Kim Jihye Kim Juri Jeong Seong Hyeon Hong Donghyun Kim Seungho Choi Inchul Choi Jeong Su Oh Chunghee Cho, Identification of a novel embryo‐prevalent gene, Gm11545, involved in preimplantation embryogenesis in mice, The FASEB JournalVolume 33, Issue 10, https://doi.org/10.1096/fj.201900370RR
■ Yuram Park, Jae-Sung Kim & Jeong Su Oh, Zw10 is a spindle assembly checkpoint protein that regulates meiotic maturation in mouse oocytes, Histochemistry and Cell Biology volume 152, pages207–215(2019)
■ Yi Na Yoon, Min Ho Choe, Kwan-Young Jung, Sang-Gu Hwang, Jeong Su Oh & Jae-Sung Kim, MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells, BMC Cancer volume 18, Article number: 716 (2018)
■ MIN HO CHOE, JOON KIM, JIYEON AHN, SANG-GU HWANG, JEONG SU OH and JAE-SUNG KIM, Centrosome Clustering Is a Tumor-selective Target for the Improvement of Radiotherapy in Breast Cancer Cells, doi:
■ Jiyeon Leem, Jae‐Sung Kim, Jeong Su Oh, WIP1 phosphatase suppresses the DNA damage response during G2/prophase arrest in mouse oocytes, Biology of Reproduction, Volume 99, Issue 4, October 2018, Pages 798–805, https://doi.org/10.1093/biolre/ioy108
■ HaiYang Wang, Min Ho Choe, In-Won Lee, Suk Namgoong, Jae-Sung Kim, Nam-Hyung Kim, Jeong Su Oh, CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation, Development 2017 144: 3829-3839; doi: 10.1242/dev.158584
■ Jeon, Hyuk-Joon; You, Seung Yeop; Kim, Dong Hyun; Jeon, Hong Bae; Oh, Jeong Su, Protective effects of ethanol extracts of Artemisia asiatica Nakai ex Pamp. on ageing-induced deterioration in mouse oocyte quality, Zygote; Cambridge Vol. 25, Iss. 4, (Aug 2017): 472-479. DOI:10.1017/S0967199417000296
■ HaiYang Wang Jing Guo ZiLi Lin Suk Namgoong Jeong Su Oh Nam‐Hyung Kim, Filamin A is required for spindle migration and asymmetric division in mouse oocytes, The FASEB JournalVolume 31, Issue 8, https://doi.org/10.1096/fj.201700056R
⑥ 대표전화 : 031-299-4852
⑦ 위치 : 62151