① 연구실명: 유전자·세포 리프로그래밍 연구실/Reprogramming Genetic Code for Disease Engineering (ReCode) Laboratory

② 지도교수명: 양유수 교수(Prof. Yang, Yoosoo)

③ 연구실 소개: 
안녕하세요 성균관대학교 생명공학대학 융합생명공학과 'ReCode 연구실' 입니다. 저희 연구팀은 혁신적인 다학제적 접근으로 면역 미세환경을 리프로그래밍해 난치성 질환의 치료 저항성을 극복하고 무너진 면역 균형을 회복하는 데 주력하고 있습니다. 이를 위해 세포외소포(EV), 항체 약물 접합체(ADC), 펩타이드 약물 접합체(PDC), 지질 나노입자(LNP) 등 리프로그래밍 플랫폼을 개발하고 PROTAC, miRNA, siRNA, mRNA와 같은 리프로그래밍 도구를 활용해 유전자 발현과 단백질 활성을 정교하게 조절합니다. 이러한 기술을 융합함으로써 세포 기능과 면역 반응을 새롭게 조정하여 난치성 질환을 겨냥한 맞춤형 표적 치료법을 창출합니다. 
Our team, “ReCode Laboratory” focuses on reprogramming the immune microenvironment to address intractable diseases. Our goal is to overcome therapeutic resistance and restore immune balance through innovative and multidisciplinary approaches. To this end, we develop advanced delivery platforms—such as extracellular vesicles (EVs), antibody-drug conjugates (ADCs), peptide-drug conjugates (PDCs), and lipid nanoparticles (LNPs)—to enable the targeted and efficient delivery of molecular reprogramming tools. These include PROTACs, microRNAs (miRNAs), small interfering RNAs (siRNAs), and messenger RNAs (mRNAs), which allow precise modulation of gene expression and protein function. By integrating these technologies, we reprogram cellular functions and immune responses, ultimately creating personalized and targeted therapies for hard-to-treat diseases.

④ 연구분야: 유전자 및 세포 리프로그래밍/Gene and Cell therapy

⑤ 대표연구 실적: 
(1) Choi, J., Park, B., Park, J. Y., Shin, D., Lee, S., Yoon, H. Y., Kim, K., Kim, S. H., Kim, Y., Yang, Y., & Shim, M. K. (2024). Light-Triggered PROTAC Nanoassemblies for Photodynamic IDO Proteolysis in Cancer Immunotherapy. Advanced materials, 36(38), e2405475. https://doi.org/10.1002/adma.202405475
(2) Jang, H., Choi, J., Park, D., Han, G., Kim, E. H., Kim, K., Kim, S. H., Shim, M. K., & Yang, Y. (2024). Milk-derived extracellular vesicles enable gut-to-tumor oral delivery of tumor-activated doxorubicin prodrugs. Theranostics, 14(14), 5413–5428. https://doi.org/10.7150/thno.97269
(3) Lee, J. W., Yoon, H. Y., Ko, Y. J., Kim, E. H., Song, S., Hue, S., Gupta, N., Malin, D., Kim, J., Kong, B., Kim, S., Kim, I. S., Kwon, I. C., Yang, Y., & Kim, S. H. (2024). Dual-Action Protein-siRNA Conjugates for Targeted Disruption of CD47-Signal Regulatory Protein α Axis in Cancer Therapy. ACS nano, 18(33), 22298–22315. https://doi.org/10.1021/acsnano.4c06471
(4) Kim, Y., Choi, J., Kim, E. H., Park, W., Jang, H., Jang, Y., Chi, S. G., Kweon, D. H., Lee, K., Kim, S. H., & Yang, Y. (2024). Design of PD-L1-Targeted Lipid Nanoparticles to Turn on PTEN for Efficient Cancer Therapy. Advanced science, 11(22), e2309917. https://doi.org/10.1002/advs.202309917
(5) Han, G., Kim, H., Jang, H., Kim, E. S., Kim, S. H., & Yang, Y. (2023). Oral TNF-α siRNA delivery via milk-derived exosomes for effective treatment of inflammatory bowel disease. Bioactive materials, 34, 138–149. https://doi.org/10.1016/j.bioactmat.2023.12.010
(6) Kim, H., Park, H. J., Chang, H. W., Back, J. H., Lee, S. J., Park, Y. E., Kim, E. H., Hong, Y., Kwak, G., Kwon, I. C., Lee, J. E., Lee, Y. S., Kim, S. Y., Yang, Y., & Kim, S. H. (2022). Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer. Bioactive materials, 25, 527–540. https://doi.org/10.1016/j.bioactmat.2022.07.021
(7) Kim, G. B., Nam, G. H., Hong, Y., Woo, J., Cho, Y., Kwon, I. C., Yang, Y., & Kim, I. S. (2020). Xenogenization of tumor cells by fusogenic exosomes in tumor microenvironment ignites and propagates antitumor immunity. Science advances, 6(27), eaaz2083. https://doi.org/10.1126/sciadv.aaz2083
(8) Hong, Y., Nam, G., Koh, E., Jeon, S., Kim, G. B., Jeong, C., Kim, D., Yang, Y., & Kim, I. (2018). Exosome as a vehicle for delivery of membrane protein therapeutics, PH20, for enhanced tumor penetration and antitumor efficacy. Advanced Functional Materials, 28(17). https://doi.org/10.1002/adfm.201801301
(9) Koh, E., Lee, E. J., Nam, G. H., Hong, Y., Cho, E., Yang, Y., & Kim, I. S. (2017). Exosome-SIRPα, a CD47 blockade increases cancer cell phagocytosis. Biomaterials, 121, 121–129. https://doi.org/10.1016/j.biomaterials.2017.01.004
(10) Yang, Y., Hong, Y., Nam, G. H., Chung, J. H., Koh, E., & Kim, I. S. (2017). Virus-Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes. Advanced materials, 29(13), 10.1002/adma.201605604. https://doi.org/10.1002/adma.201605604

⑥ 대표전화: 추후안내

⑦ 위치: 생명공학관 61동 1층 61106A, B호