[행사/세미나] IPHC Seminar Series / 5. 4.
- 지능형정밀헬스케어융합학과
- 조회수953
- 2021-04-15
Enhancing Cancer Immunotherapy using Biomaterials and Drug Delivery Technologies
(Prof. Chunkwon Park, Sungkyunkwan University)
- 교강사 : 박천권 교수
- 주제 : Enhancing Cancer Immunotherapy using Biomaterials and Drug Delivery Technologies
- 일시 : 2021. 5. 4.(화) 15시
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Unlike traditional approaches in oncology, cancer immunotherapy harnesses a patient’s coordinated and adaptive immune system in order to combat the disease. Recent clinical data have supported the utility of this therapeutic modality. The benefits of cancer immunotherapy include the potential 1) to treat all types of cancer, regardless of the underlying mutations or cell of origin; 2) to prevent metastasis and relapse by generating memory antitumor immunity; and 3) to decrease side effects relative to conventional cytotoxic treatment approaches (e.g., chemotherapy and radiotherapy).
Still, the therapeutic index of cancer immunotherapy must be improved, since the proportion of patients responding to this approach remains unsatisfactory and the therapy often causes systemic toxicity following parental administration. To address these issues, we used various biomaterials-based drug delivery approaches to deliver immunomodulatory compounds in a spatiotemporally controlled manner in order to improve their efficacy and safety relative to conventional systemic administration.
References
1. Extended Release of Perioperative Immunotherapy Prevents Tumor Recurrence and Eliminates Metastases, Science Translational Medicine, 10 (433), eaar1916, 2018
2. T cell-targeting Nanoparticles Focus Delivery of Immunotherapy to Improve Antitumor Immunity, Nature Communications, 1747, 2017