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- (이종성 교수) 분자 피부 과학 연구실 소개
- ① 연구실명 : 분자 피부 과학 연구실(Molecular Dermatology Lab) ② 지도교수명 : 이종성 교수님(Prof. Lee, jongsung) ③ 연구실 소개 안녕하세요 성균관대학교 생명공학대학 융합생명공학과 이종성 교수님 '분자 피부 과학 연구실' 입니다. 저희 연구실에서는 외부 자극에 의해 발생하는 다양한 피부 이상 현상 (피부암, 피부 자가면역질환, 노화, 피부염증 질환, 색소이상 등)의 발생 기전에 대해 연구하고 있으며 더 나아가 피부이상을 개선할 수 있는 소재개발에 관한 연구도 진행하고 있습니다. 또한, 피부 및 피하조직 세포들의 매커니즘 연구를 통하여 전반적인 피부의 항상성 유지 및 피부를 개선할 수 있는 연구에 초점을 맞추고 있습니다. 졸업 후에는 생명공학 및 코스매틱 기반의 연구실이나 연구 시설 등으로 진출합니다. This is the 'Molecular Dermatology Laboratory' of Professor Jong-Sung Lee, Department of integrative Biotechnology, College of Biotechnology, Sungkyunkwan University. In our laboratory, we research the mechanisms of occurrence of various skin abnormalities such as skin cancer, skin autoimmune diseases, aging, skin inflammatory diseases, pigment abnormalities, etc. caused by external stressors and further develop materials that can improve skin conditions. In addition, we focus on research that can improve the skin condition and maintain overall skin homeostasis through research on the mechanisms of skin and subcutaneous tissue cells. After graduation, our alumni can work in biotech and cosmetics-based laboratories or research facilities. ④ 연구분야 피부 생리 및 항상성 연구/ 피부 색소(멜라닌) 형성 / 피부 염증 및 자가면역질환 / 노화 skin physiology & homeostasis mechanism / melanogenesis / skin inflammatory and autoimmune disease / aging ⑤ 대표연구 실적 ■ The Role of Leptin in the Association between Obesity and Psoriasis. Hwang J, Yoo JA, Yoon H, Han T, Yoon J, An S, Cho JY, Lee J. Biomol Ther (Seoul). 2020 Jul 21. doi: 10.4062/biomolther.2020.054. Online ahead of print. ■ Glucose Exerts an Anti-Melanogenic Effect by Indirect Inactivation of Tyrosinase in Melanocytes and a Human Skin Equivalent. Lee SH, Bae IH, Lee ES, Kim HJ, Lee J, Lee CS. Int J Mol Sci. 2020 Mar 3;21(5):1736. doi: 10.3390/ijms21051736. ■ Melanogenic Effects of Maclurin Are Mediated through the Activation of cAMP/PKA/CREB and p38 MAPK/CREB Signaling Pathways. Hwang YS, Oh SW, Park SH, Lee J, Yoo JA, Kwon K, Park SJ, Kim J, Yu E, Cho JY, Lee J. Oxid Med Cell Longev. 2019 Dec 22;2019:9827519. doi: 10.1155/2019/9827519. eCollection 2019. ■ Antagonizing Effects of Clematis apiifolia DC. Extract against Benzo[a]pyrene-Induced Damage to Human Keratinocytes. Lee SE, Park SH, Yoo JA, Kwon K, Kim JW, Oh SW, Park SJ, Kim J, Yu E, Han BS, Cho JY, Lee J. Oxid Med Cell Longev. 2019 Nov 5;2019:2386163. doi: 10.1155/2019/2386163. eCollection 2019. ■ Interleukin4Rα (IL4Rα) and IL13Rα1 Are Associated with the Progress of Renal Cell Carcinoma through Janus Kinase 2 (JAK2)/Forkhead Box O3 (FOXO3) Pathways. Kang MA, Lee J, Ha SH, Lee CM, Kim KM, Jang KY, Park SH. Cancers (Basel). 2019 Sep 18;11(9):1394. doi: 10.3390/cancers11091394. ■ Beauvericin inhibits melanogenesis by regulating cAMP/PKA/CREB and LXR-α/p38 MAPK-mediated pathways. Lee SE, Park SH, Oh SW, Yoo JA, Kwon K, Park SJ, Kim J, Lee HS, Cho JY, Lee J. Sci Rep. 2018 Oct 8;8(1):14958. doi: 10.1038/s41598-018-33352-8. ■ Globular adiponectin acts as a melanogenic signal in human epidermal melanocytes. Kim Y, Cho JY, Oh SW, Kang M, Lee SE, Jung E, Park YS, Lee J. Br J Dermatol. 2018 Sep;179(3):689-701. doi: 10.1111/bjd.16488. Epub 2018 Jul 4. ■ Stemness and differentiation potential-recovery effects of sinapic acid against ultraviolet-A-induced damage through the regulation of p38 MAPK and NF-κB. Hwang YS, Park SH, Kang M, Oh SW, Jung K, Park YS, Lee J. Sci Rep. 2017 Apr 19;7(1):909. doi: 10.1038/s41598-017-01089-5. ⑥ 대표전화 : 031-290-7891 ⑦ 위치 : 62251B
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- 작성일 2020-08-31
- 조회수 3773
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- (권대혁 교수) 단백질공학 연구실 소개
- ① 연구실명 : 단백질공학 연구실 (Protein Engineering Lab) ② 지도교수명 : 권대혁 교수님 (Prof. Dae-Hyuk Kweon) ③ 연구실 및 대표 연구분야 소개 안녕하세요, 저희는 성균관대학교 생명공학대학 융합생명공학과 권대혁 교수님 ‘단백질공학 연구실’ 입니다. 저희는 총 세 팀으로 나뉘어 바이러스, 보톡스, 효소 분야를 연구하고 있습니다. 먼저 바이러스 팀은 바이러스의 envelope membrane에 구멍을 뚫어 바이러스를 물리적으로 사멸하는 항바이러스제를 개발하고 있습니다. 직경이 약 15 nm 크기로 인지질로 이루어진 이 나노 구조체는 낮은 pH 환경에서 바이러스의 막과의 융합이 가능한 구조를 지닙니다. 뿐만 아니라 원하는 수용체로 호환이 가능하다는 특징으로 인해 변종을 포함한 여러 인플루엔자 바이러스에 적용 가능한 나노 구조체 개발을 목표로 하고 있습니다. 현재 코로나 바이러스의 수용체인 ACE2를 나노 구조체에 적용하려는 시도 중에 있으며, 코로나 바이러스의 pseudovirus를 통해 항바이러스 효과를 확인하는 연구를 하고 있습니다. 보톡스 팀은 보툴리눔 신경독소를 합성하기 위해 각 도메인 별로 분할생산하고, 이를 기존의 전장 독소의 형태로 만드는 방법을 연구하며, 보툴리눔 독소의 도메인 중 전이기전을 가진 도메인을 활용하여 세포 내의 세포질로 단백질을 전달할 수 있는 단백질 전달 시스템을 연구하고 있습니다. 마지막으로 효소 팀은 단백질을 쉽게 이용하고자 특성을 개량할 때, 무작위적인 돌연변이체를 빠르고 정확하게 선별하는 것을 목적으로 하여 기존의 플라스미드 디스플레이 시스템을 보완하여 두 가지 단백질 발현 시스템을 이용하여 돌연변이체의 특성만을 따라 선별하는 플라스미드 디스플레이 시스템에 대해 연구하고 있습니다. 또한, 모유 올리고당과 결합하는 단백질을 이용하여 Protein-Ligand 반응 시 단백질의 침전이 지연된다는 원리를 바탕으로 모유 올리고당을 검출하는 시스템을 개발하고 있습니다. 연구실 대표 전화는 031-290-4850이오니 위 연구 분야에 관심 있는 분들께서는 언제든지 연락주시기 바랍니다. 감사합니다. "Protein Engineering Lab" is a laboratory in the department of Integrative Biotechnology, Sungkyunkwan University. We are divided into three teams working on viruses, botox and enzymes. First, the virus team is developing an antiviral agent that physically kills the virus by punching a hole in the envelope membrane of the virus. This nanostructure, made of phospholipids with a diameter of about 15 nm, has a structure capable of fusion with the virus membrane in a low pH environment. In addition, we aim to develop nanostructures that can be applied to various influenza viruses including strains due to their compatibility with desired receptors. Currently, we are trying to apply ACE2, a receptor for coronavirus, to nanostructures and we are conducting research to test the antiviral effect through a pseudovirus of coronavirus. In order to synthesize Botulinum neurotoxin, the Botox team divides and produces botulinum neurotoxin for each domain, and researches how to make it into the form of a conventional full-length toxin. We are researching a protein delivery system that can deliver proteins to the cytoplasm within cells by utilizing domains with a transfer mechanism among the domains of botulinum toxin. Finally, the enzyme team supplements the existing plasmid display system with the aim of quickly and accurately selecting random mutants when improving their properties to use proteins easily and using only the characteristics of the mutants using two protein expression systems. We are working on a plasmid display system to screen accordingly. In addition, we are developing a system that detects human milk oligosaccharides based on the principle that protein precipitation is delayed during the Protein-Ligand reaction using proteins that bind to human milk oligosaccharides. The representative phone number for the lab is 031-299-4850, so if you are interested in the above research fields, please feel free to contact us. Thank you. ④ 대표연구 실적 ■ Enhancing the oral bioavailability of curcumin using solid lipid nanoparticles. ChoongjinBan, Myeongsu Jo, Young Hyun Park, Jae Hwan Kim, Jae Yong Han, Ki Won Lee, Dae-Hyuk Kweon, Young Jin Choi. Food Chemistry, 2020, 302, 125328 ■ Envelope-deforming antiviral peptide derived from influenza virus M2 protein. Younghun Jung; Byoungjae Kong; Seokoh Moon; Seok-Hyuk Yu; Jinhyo Chung; Choongjin Ban; Woo-Jae Chung; Sung-Gun Kim; Dae-Hyuk Kweon. Biochemical and Biophysical Research Communications ■ Development of a quantitative assay for 2´-fucosyllactose via one-pot reaction with α1,2-fucosidase and L-fucose Younghun Jung; Byoungjae Kong; Seokoh Moon; Seok-Hyuk Yu; Jinhyo Chung; Choongjin Ban; Woo-Jae Chung; Sung-Gun Kim; Dae-Hyuk Kweon. Analytical Biochemistry. 2019 582 113358 ■ Jae-Bum Park, Jin-Seong Kim, Deok-Ho Kweon, Dae-Hyuk Kweon, Jin-Ho Seo, Suk-Jin Ha. Overexpression of endogenous xylose reductase dnhanced xylitol productivity at 40 °C by thermotolerant yeast Kluyveromyces marxianus. Applied Biochemistry and Biotechnology. 2019 in press. ■ Jonghyeok shin, Jiwon Yu, Myungseo Park, Chakhee Kim, Hooyeon Kim, Yunjeong Park, Choongjin Ban, Emine Seydametova, Young-Ha Song, Chul-Soo Shin, Kyung Hwun Chung, Ji-Min Woo, Hyunwoo Chung, Jin-Byung Park, Dae-Hyuk Kweon. Endocytosing Escherichia coli as a whole-cell biocatalyst of fatty acids. ACS Synthetic Biology. 2019 8(5) 1055-1066. ⑤ 대표 전화 : 031-299-4850 ⑥ 위치 : 성균관대학교 62동 62254
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- 작성일 2020-08-31
- 조회수 3777
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- (조재열 교수) 분자면역학 연구실 소개
- ① 연구실명 : 분자면역학 연구실(Molecular Immunology Lab) ② 지도교수명 : 조재열 교수님(Prof. Cho, Jae Youl) ③ 연구실 소개 안녕하세요, 저희는 성균관대학교 생명공학대학 융합생명공학과 조재열 교수님의 '분자면역학 연구실'입니다. 분자면역학 연구실에서는 1) 암 및 염증과정에서의 비히스톤 단백질 메틸화 반응, 2) 종양 형성 반응의 조절, 3) 자가포식 과정을 통한 세포노화 현상의 이해 및 항노화 소재 개발 4) Toll-like-Receptor(TLR) 매개의 염증 신호 전달 과정 조절기전 5) 항노화 기능성 화장품 소재 개발에 관한 연구를 진행하고 있습니다. 졸업 후 식품, 화장품 및 제약 연구 기반의 연구소, 회사 등 다양한 스펙트럼의 기업체로 진출할 수 있습니다. 저희 연구실의 대표 전화는 031-290-7878이며 이메일 주소는 jaecho@skku.edu이오니 관심있는 분들께서는 언제든 연락주시기 바랍니다. 감사합니다. For recent 10 years, the research areas of "Molecular Immunology Laboratory" has been focused on the functional understanding of innate immune response, autophagy, and post translational modification like protein methylation in cancer and inflammation resulting in more than 450 original publications and 135 patents. We aim to understand underlying mechanism of each project in cancer and inflammation : 1) Methylation of non-histone protein via post-translational modification 2) Regulation of tumorigenic responses 3) Signaling of toll-like receptor (TLR)-mediated inflammatory response 4) Regulartory effect of autophagic response in cellular senesence 5) Development of anti-photoaging and anti-inflammatory functional raw materials To address these issues, we use diverse molecular biological and immunological experimental techniques, animal disease models, and collaborate with other research teams. A lot of our lab alumni have been working on various fields including university, pharmaceutical companies, NPO/NGO institutions. ④ 연구분야 비히스톤 단백질 메틸화 반응 / 자가포식 / TLR 매개 염증반응 / 기능성 화장품 소재 개발/ 종양 형성 반응 Non-histone protein methylation / Autophagy / TLR-mediated Inflammatory Responses / Anti-photoaging & Cosmetics / Tumorigenic Responses ⑤ 대표연구 실적 ■ Park JG*, Aziz N*, Cho JY. MKK7, the essential regulator of JNK signaling involved in cancer cell survival: a newly emerging anticancer therapeutic target. Ther Adv Med Oncol. 2019;11:1758835919875574. Published 2019 Sep 24. doi:10.1177/1758835919875574 Impact Factor - 6.52 ■ Yang WS*, Kim HG*, Kim E*,.... and Cho JY Isoprenylcysteine Carboxyl Methyltransferase and Its Substrate Ras Are Critical Players Regulating TLR-Mediated Inflammatory Responses. Cells. 2020;9(5):1216. Published 2020 May 14. doi:10.3390/cells9051216 Impact Factor - 4.829 ■ Qomaladewi NP, Kim MY, Cho JY. Autophagy and its regulation by ginseng components. J Ginseng Res. 2019;43(3):349-353. doi:10.1016/j.jgr.2018.12.011 Impact Factor - 5.487 ■ Lee JH*, Yu SE*, Kim KH*, ...., Cho JY, .... Woo SM and Yoo BC. Individualized metabolic profiling stratifies pancreatic and biliary tract cancer: a useful tool for innovative screening programs and predictive strategies in healthcare. EPMA J. 2018;9(3):287-297. Published 2018 Aug 17. doi:10.1007/s13167-018-0147-5 Impact Factor - 7.70 ■ Jeong D, Lee J, Park SH,... and Cho JY. Antiphotoaging and Antimelanogenic Effects of Penthorum chinense Pursh Ethanol Extract due to Antioxidant- and Autophagy-Inducing Properties. Oxid Med Cell Longev. 2019;2019:9679731. Published 2019 Apr 3. doi:10.1155/2019/9679731 Impact Factor - 4.868 ■ Kim E, Yi YS, Son YJ, .... and Cho JY. BIOGF1K, a compound K-rich fraction of ginseng, plays an antiinflammatory role by targeting an activator protein-1 signaling pathway in RAW264.7 macrophage-like cells. J Ginseng Res. 2018;42(2):233-237. doi:10.1016/j.jgr.2018.02.001 Impact Factor - 5.487 Hong YH, Kim D, Nam G, .... and Cho JY. Photoaging protective effects of BIOGF1K, a compound-K-rich fraction prepared from Panax ginseng. J Ginseng Res. 2018;42(1):81-89. doi:10.1016/j.jgr.2017.01.002 Imapct Factor - 5.487 ■ Kim E, Jang J, Park JG, …., and Cho JY. Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling. Int J Mol Sci. 2020;21(9):3058. Published 2020 Apr 26. doi:10.3390/ijms21093058 Impact Factor - 4.868 ■ Choi E*, Kim E*, Kim JH, …. and Cho JY. AKT1-targeted proapoptotic activity of compound K in human breast cancer cells. J Ginseng Res. 2019;43(4):692-698. doi:10.1016/j.jgr.2019.07.001 Impact Factor - 5.487 ■ Aziz N, Hong YH, Jo M, .... and Cho JY Molecular Signatures of JMJD10/MINA53 in Gastric Cancer. Cancers (Basel). 2020;12(5):1141. Published 2020 May 2. doi:10.3390/cancers12051141 Impact Factor - 6.126 ■ Park SH*, Kim DS*, Kim S*, …. and Cho JY. Loliolide Presents Antiapoptosis and Antiscratching Effects in Human Keratinocytes. Int J Mol Sci. 2019;20(3):651. Published 2019 Feb 2. doi:10.3390/ijms20030651 Impact Factor - 4.868 ■ Jeong D*, Qomaladewi NP*, Lee J, Park SH, Cho JY. The role of autophagy in skin fibroblasts, keratinocytes, melanocytes, and epidermal stem cells. Journal of Investigative Dermatology Sep. 1, 140(9) 1691-1697 (2020) Published 2020 Sep 1. doi: 10.1016/j.jid.2019.11.023. Impact Factor - 7.143 ■ Ratan ZA*, Son YJ*, Haidere MF, …. and Cho JY. CRISPR-Cas9: a promising genetic engineering approach in cancer research. Ther Adv Med Oncol. 2018;10:1758834018755089. Published 2018 Feb 5. doi:10.1177/1758834018755089 Impact Factor - 6.52 ⑥ 대표전화 : 031-290-7878 ⑦ 위치 : 62153,62154, 62105
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- 작성일 2020-08-31
- 조회수 3950
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- (전영준 교수) RNA 치료 및 정밀 의학 연구실 소개
- ① 연구실명 : RNA 치료 및 정밀 의학 연구실(RNA-therapeutics and Precision Medicine Lab) ② 지도교수명 : 전영준 교수(Prof. Jeon, Young-Jun) ③ 연구실 소개 안녕하세요, 저희는 성균관대학교 생명공학대학 융합생명공학과 전영준 교수님 'RNA 치료 및 정밀 의학 연구실' 입니다. 저희는 주로 암 세포 생물학과 차세대 염기서열 분석 및 생명정보학적 방법을 이용하여 항암 치료 및 저항기전을 연구하며, 의과대학과 협업하여 관련 내용을 액체생검 방식을 이용하여 환자 수준에서 확인하는 이른바 정밀의학을 연구하는 lab입니다. 졸업 후 의.약학 연구 기반의 연구실이나, 회사등으로 진출합니다. 저희 연구실의 대표 전화는 031-290-7862이며 이메일 주소는 jeon2020@skku.edu이오니 관심있는 분들께서는 언제든 연락주시기 바랍니다. 감사합니다. "RNA-theraputics & Precision Medicine (RPM)" is a newly established laboratory in the department of Integrative Biotechnology, Sungkyunkwan University. The overarching goal of our research team is to develop a better understanding of cancer progression mainly focusing on therapeutics using transcriptomic approaches with invasive and/or non-invasive method. We employ cancer cell biology, tools of genomics and Bioinformatics from pre-processed data sets and cancer tissues / cell lines. Importantly, we aim to apply all this knowledge to patient level by analyzing cell free mRNAs from patient plasma. The projects will be performed on a collaboration basis with Samsung Hospital domestically and Stanford School of Medicine / The Ohio State University School of Medicine internationally. Our alumni are expecting to become an independent researcher working on a university, profit organization / company as well as a research laboratory. Our ultimate goal is to develop a better strategy to treat patients with cancers as a translational approach on the basis of precision medicine. ④ 연구분야 암 정밀 의학 / 항암 치료 및 저항 기전 / 암 세포 생물학 / 액체 생검 / 차세대 염기서열 분석 Precision medicine / Drug resistance / Cancer Cell Biology / Liquid Biopsy / Circulating tumor nucleic acids / NGS ⑤ 대표연구 실적 ■ Jeon YJ*, Binkely MS*, …. Diehn M. KEAP1/NFE2L2 mutations predict high risk for local recurrence after radiation therapy but not surgery in non-small cell lung cancer. *Equal Contribution Cancer Discovery, in-revision with minor comments, Impact factor - 29.497 ■ Nabet BY*, Eshfahani MS*, ….Jeon YJ…. Alizadeh AA# and Diehn M#. A noninvasive approach for early prediction of therapeutic benefit from immune checkpoint blockade for lung cancer. Cell, in-revision ■ Chabon JJ*, Hamilton EG*, Kurtz DM*, Esfahani MS*…., Jeon YJ…., Alizadeh AA and Diehn M. Integrating genomic features for non-invasive early lung cancer detection. Nature. 2020 Apr;580(7802):245-251. doi: 10.1038/s41586-020-2140-0. Epub 2020 Mar 25. ■ Jeon YJ*, Esfahani MS*, Lee L*, …., Alizadeh AA and Diehn M. Functional Significance of U2AF1 S34F Mutations in Lung Adenocarcinoma. Nat Commun. 2019 Dec 13;10(1):5712. doi: 10.1038/s41467-019-13392-y. * Equal contribution, Impact factor - 12.121 ■ Jeon YJ*, Kim T*, …., Cui R and Croce CM. miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC. * Equal contribution Nat Commun. 2018 Nov 30;9(1):5110. doi: 10.1038/s41467-018-07561-8. Impact factor - 11.878 ■ Jeon YJ, Kim S, Kim JH, Youn UJ and Suh S-S. The Comprehensive Roles of ATRANORIN, A Secondary Metabolite from the Antarctic Lichen Stereocaulon caespitosum, in HCC Tumorigenesis. Molecules. 2019 Apr 10;24(7). pii: E1414. doi: 10.3390/molecules24071414. Impact factor - 3.267 ■ Sun HL, …., Jeon YJ, …. Peng Y and Croce CM. ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5. Cancer Cell. 2016 Nov 14;30(5):723-736. doi: 10.1016/j.ccell.2016.10.001. ■ Jeon YJ*, Joshi P*, …., Croce CM. MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8650-5. doi: 10.1073/pnas.1500886112. * Equal Contribution, Impact factor - 9.423 ■ Jeon YJ, …., Garofalo M and Croce CM. A set of NF-κB-regulated microRNAs Induces Acquired TRAIL Resistance in Lung Cancer. Proc Natl Acad Sci U S A. published ahead of print 2015 Jun 15, doi:10.1073/pnas.1504630112. Impact factor - 9.423 ■ Jeon YJ*, Kim T*,…., Croce CM. Role of MYC-Regulated Long Noncoding RNAs in Cell Cycle Regulation and Tumorigenesis. J Natl Cancer Inst. 2015 Feb 6;107(4). * Equal Contribution. Impact factor - 11.370 ■ Jeon YJ*, Garofalo M*,…., Croce CM. MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. PLoS One. 2013 Jun 21;8(6):e67581. doi: 10.1371/journal.pone.006758 * Equal Contribution. Impact factor - 3.534 ■ Jeon YJ*, Kim IK*, …., Jung YK. Ribosomal protein S6 is a selective mediator of TRAIL-apoptotic signaling. Oncogene. 2008 Jul 17;27(31):4344-52. * Equal Contribution. Impact factor - 6.371 ⑥ 대표전화 : 031-290-7871 ⑦ 위치 : 생명공학관 62동 108호
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- 작성일 2020-08-26
- 조회수 4146