① 연구실명 : 분자면역학 연구실(Molecular Immunology Lab)
② 지도교수명 : 조재열 교수님(Prof. Cho, Jae Youl)
③ 연구실 소개
안녕하세요, 저희는 성균관대학교 생명공학대학 융합생명공학과 조재열 교수님의 '분자면역학 연구실'입니다. 분자면역학 연구실에서는 1) 암 및 염증과정에서의 비히스톤 단백질 메틸화 반응, 2) 종양 형성 반응의 조절, 3) 자가포식 과정을 통한 세포노화 현상의 이해 및 항노화 소재 개발 4) Toll-like-Receptor(TLR) 매개의 염증 신호 전달 과정 조절기전 5) 항노화 기능성 화장품 소재 개발에 관한 연구를 진행하고 있습니다. 졸업 후 식품, 화장품 및 제약 연구 기반의 연구소, 회사 등 다양한 스펙트럼의 기업체로 진출할 수 있습니다. 저희 연구실의 대표 전화는 031-290-7878이며 이메일 주소는 jaecho@skku.edu이오니 관심있는 분들께서는 언제든 연락주시기 바랍니다. 감사합니다.
For recent 10 years, the research areas of "Molecular Immunology Laboratory" has been focused on the functional understanding of innate immune response, autophagy, and post translational modification like protein methylation in cancer and inflammation resulting in more than 450 original publications and 135 patents.
We aim to understand underlying mechanism of each project in cancer and inflammation :
1) Methylation of non-histone protein via post-translational modification
2) Regulation of tumorigenic responses
3) Signaling of toll-like receptor (TLR)-mediated inflammatory response
4) Regulartory effect of autophagic response in cellular senesence
5) Development of anti-photoaging and anti-inflammatory functional raw materials
To address these issues, we use diverse molecular biological and immunological experimental techniques, animal disease models, and collaborate with other research teams.
A lot of our lab alumni have been working on various fields including university, pharmaceutical companies, NPO/NGO institutions.
④ 연구분야
비히스톤 단백질 메틸화 반응 / 자가포식 / TLR 매개 염증반응 / 기능성 화장품 소재 개발/ 종양 형성 반응
Non-histone protein methylation / Autophagy / TLR-mediated Inflammatory Responses / Anti-photoaging & Cosmetics / Tumorigenic Responses
⑤ 대표연구 실적
■ Park JG*, Aziz N*, Cho JY. MKK7, the essential regulator of JNK signaling involved in cancer cell survival: a newly emerging anticancer therapeutic target. Ther Adv Med Oncol. 2019;11:1758835919875574. Published 2019 Sep 24. doi:10.1177/1758835919875574 Impact Factor - 6.52
■ Yang WS*, Kim HG*, Kim E*,.... and Cho JY Isoprenylcysteine Carboxyl Methyltransferase and Its Substrate Ras Are Critical Players Regulating TLR-Mediated Inflammatory Responses. Cells. 2020;9(5):1216. Published 2020 May 14. doi:10.3390/cells9051216 Impact Factor - 4.829
■ Qomaladewi NP, Kim MY, Cho JY. Autophagy and its regulation by ginseng components. J Ginseng Res. 2019;43(3):349-353. doi:10.1016/j.jgr.2018.12.011 Impact Factor - 5.487
■ Lee JH*, Yu SE*, Kim KH*, ...., Cho JY, .... Woo SM and Yoo BC. Individualized metabolic profiling stratifies pancreatic and biliary tract cancer: a useful tool for innovative screening programs and predictive strategies in healthcare. EPMA J. 2018;9(3):287-297. Published 2018 Aug 17. doi:10.1007/s13167-018-0147-5 Impact Factor - 7.70
■ Jeong D, Lee J, Park SH,... and Cho JY. Antiphotoaging and Antimelanogenic Effects of Penthorum chinense Pursh Ethanol Extract due to Antioxidant- and Autophagy-Inducing Properties. Oxid Med Cell Longev. 2019;2019:9679731. Published 2019 Apr 3. doi:10.1155/2019/9679731 Impact Factor - 4.868
■ Kim E, Yi YS, Son YJ, .... and Cho JY. BIOGF1K, a compound K-rich fraction of ginseng, plays an antiinflammatory role by targeting an activator protein-1 signaling pathway in RAW264.7 macrophage-like cells. J Ginseng Res. 2018;42(2):233-237. doi:10.1016/j.jgr.2018.02.001 Impact Factor - 5.487
Hong YH, Kim D, Nam G, .... and Cho JY. Photoaging protective effects of BIOGF1K, a compound-K-rich fraction prepared from Panax ginseng. J Ginseng Res. 2018;42(1):81-89. doi:10.1016/j.jgr.2017.01.002 Imapct Factor - 5.487
■ Kim E, Jang J, Park JG, …., and Cho JY. Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling. Int J Mol Sci. 2020;21(9):3058. Published 2020 Apr 26. doi:10.3390/ijms21093058 Impact Factor - 4.868
■ Choi E*, Kim E*, Kim JH, …. and Cho JY. AKT1-targeted proapoptotic activity of compound K in human breast cancer cells. J Ginseng Res. 2019;43(4):692-698. doi:10.1016/j.jgr.2019.07.001 Impact Factor - 5.487
■ Aziz N, Hong YH, Jo M, .... and Cho JY Molecular Signatures of JMJD10/MINA53 in Gastric Cancer. Cancers (Basel). 2020;12(5):1141. Published 2020 May 2. doi:10.3390/cancers12051141 Impact Factor - 6.126
■ Park SH*, Kim DS*, Kim S*, …. and Cho JY. Loliolide Presents Antiapoptosis and Antiscratching Effects in Human Keratinocytes. Int J Mol Sci. 2019;20(3):651. Published 2019 Feb 2. doi:10.3390/ijms20030651 Impact Factor - 4.868
■ Jeong D*, Qomaladewi NP*, Lee J, Park SH, Cho JY. The role of autophagy in skin fibroblasts, keratinocytes, melanocytes, and epidermal stem cells. Journal of Investigative Dermatology Sep. 1, 140(9) 1691-1697 (2020) Published 2020 Sep 1. doi: 10.1016/j.jid.2019.11.023. Impact Factor - 7.143
■ Ratan ZA*, Son YJ*, Haidere MF, …. and Cho JY. CRISPR-Cas9: a promising genetic engineering approach in cancer research. Ther Adv Med Oncol. 2018;10:1758834018755089. Published 2018 Feb 5. doi:10.1177/1758834018755089 Impact Factor - 6.52
⑥ 대표전화 : 031-290-7878
⑦ 위치 : 62153,62154, 62105