Professor Kim In Su's research team decorates the cover of the Journal of Organic Chemistry
- 약학대학
- Hit3141
- 2021-07-02
A research led by Professor Kim In Su decorated the cover paper for the June issue of The Journal of Organic Chemistry, one of leading journals in chemistry, published by the American Chemical Society. (First author: Jeoung Daeun, Kim Kunyoung, master's course)
His research team developed "a new method of amidation reaction using direct conversion reactions of carbon-hydrogen bonds." The method is a single-step, site-selective conversion reaction of phthalazine framework, a ubiquitous structural motif found in various pharmaceuticals and natural products, which allows introduction of new amine functional group. This groundbreaking discovery allows synthesis of heterocycles with various biological activities and provides great potential for applications in drug discovery.
Professor Kim In Su said, "The result is an optimal synthesis methodology which can derive new antitumor compounds through the conversion of phthalazinone structures, known as the core structure of drugs."
The research was carried out by the support of the Ministry of Science and ICT (Minister Yoo Young-min) and the Korea Research Foundation (Chairman Noh Jeong-hye) for Basic Research Laboratory (BRL) support and Midcareer Researcher Grant.