Professor Cho Eun-jung's research team released a paper on the Nuclear Accidents Research
- 약학대학
- Hit3391
- 2020-01-03
Discovered RNA material that induces muscle cell differentiation and muscle formation
- Large-scale Chromatin 3D Reorganization RNA induces muscle production -
Professor Cho Eun-jung's research team discovered a new non-translational RNA that facilitates muscle cell differentiation and induces muscle tissue formation by reprogramming gene expression by inducing massive reorganization of chromatin chromosomes in the nucleus.
Muscle stem cells exist in a single-body cell state and regenerate and replenish new muscle tissue through cell division and cell fusion at a time when muscle regeneration is necessary due to muscle damage and other reasons. At this time, a large-scale change in chromatin chromosomes occurs and the gene expression program shifts toward muscle formation, the detailed molecular mechanism of which is unknown. In response, the research team discovered Chromatin Re-organization 1 (ChRO1), a new non-translational RNA that induces 3D changes in large chromatin chromosomes.
Through cell and animal experiments, the researchers found that the CHRO1 RNA combines with the hormone-controlled protein DAXX/ATRX to fuse large-scale chromatin domains and alter the 3D composition of the nucleus to promote the expression of muscle genes.
This study was published online on October 18th, the world's leading journal in molecular biology.