Professor Jung Ga-young's research team published a paper in Cell.
- 약학대학
- Hit3426
- 2020-01-05
Professor Jung Ga-young’s research team announced in the world’s top international journal "CELL" on May 5 that it has identified sequential changes in structure from the G protein to inducing reactions within the cell by combining it with the G protein as an external signal, and presented the structure of G protein receptors that can be used for drug development.
The 2012 Nobel Prize in Chemistry was awarded by Robert J. Lefkowitz, a professor at Duke University, and K. Kobilka, a professor at Stanford University, who revealed the structure of the G protein receptor. Until then, it was known that the G protein was related to various diseases, but the principle of its operation had not been revealed.
The study can be seen as a step further from the 2012 Nobel Prize-winning study. Studies have shown that the structure of the Nobel Prize-winning G protein receptor may not be an appropriate model for the development of effective new drugs in the final form after coupling with G protein, and that the structure of the early G protein receptor in the combination is more suitable.
"We proposed a theory that changes the paradigm of the principle of activating G protein by G protein receptors, which have been continuously studied since the 2012 Nobel Prize in Chemistry," and "It will be a new strategy for the development of medicines that work on G protein receptors in the future" said Professor Jung Ga-young.